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Neonatal Sequelae in Association with Maternal Autoantibodies: A Series of Three Cases |
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SHIVAASHANKARI DHARMALINGAM 1. Associate Professor, Department of Paediatrics, Srinivasan Medical College and Hospital, Dhanalakshmi Srinivasan University, Samayapuram, Tiruchirappalli, TamilNadu, India. |
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Correspondence Address : Shivaashankari Dharmalingam, Associate Professor, Department of Paediatrics, Srinivasan Medical College and Hospital, Dhanalakshmi Srinivasan University, Samayapuram, Tiruchirappalli, Tamil Nadu, India. E-mail: drshankaripeds@gmail.com |
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| ABSTRACT |  | ||||||
: Neonates born to mothers with autoantibody-associated syndromes may develop clinical manifestations due to transplacental transfer of maternal antibodies. These include Congenital Heart Block (CHB), cutaneous lesions, haematological abnormalities, and hepatic dysfunction. CHB remains the most serious and potentially life-threatening manifestation. The present study is a series of three neonates born to mothers with anti-Ro/SSA, anti-La/SSB, and Antiphospholipid Syndrome (APS). The clinical spectrum ranged from second-degree atrioventricular block with a structural cardiac defect to complete CHB requiring cardiology management, as well as a neonate without cardiac involvement. Growth parameters varied from Small for Gestational Age (SGA) to Appropriate for Gestational Age (AGA). This series illustrates the variability of cardiac and non-cardiac manifestations in neonates born to mothers with autoimmune conditions and emphasises the need for careful clinical monitoring and multidisciplinary care to optimise neonatal outcomes. | |||||||
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| Keywords : Anti-Ro/SSA antibodies, Antiphospholipid syndrome, Congenital heart block, Foetal bradycardia, Neonatal lupus | |||||||
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DOI and Others :
DOI: 10.7860/IJNMR/2026/84498.2482
Date of Submission: Sep 19, 2025 Date of Peer Review: Jan 19, 2026 Date of Acceptance: Jul 28, 2026 Date of Publishing: Sep 30, 2026 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. Yes PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Sep 20, 2025 • Manual Googling: Jul 21, 2026 • iThenticate Software: Jul 27, 2026 (1%) ETYMOLOGY: Author Origin EMENDATIONS: 7 |
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