Case report Year :2026 Month : January Volume : 14 Issue : 1 Page : PC01 - PC02 Full Version Isolated Aplasia Cutis Congenita of the Lower Limb in a Newborn: A Case Report Priyanka, Neeraj Singh, Yogesh Verma, Naveen Chander, Kapil Bhalla 1. Postgraduate Student, Department of Paediatrics, PGIMS Rohtak, Rohtak, Haryana, India. 2. Assistant Professor, Department of Paediatrics, PGIMS Rohtak, Rohtak, Haryana, India. 3. Senior Resident, Department of Paediatrics, PGIMS Rohtak, Rohtak, Haryana, India. 4. Postgraduate Student, Department of Paediatrics, PGIMS Rohtak, Rohtak, Haryana, India. 5. Professor, Department of Paediatrics, PGIMS Rohtak, Rohtak, Haryana, India.   Correspondence Address : Dr. Priyanka, PGIMS, Rohtak-124001, Haryana, India. E-mail: priyanka.alhan1999@gmail.com   ABSTRACT : Aplasia Cutis Congenita (ACC) is a rare congenital disorder characterised by a lack of skin at birth, most commonly affecting the scalp, though other body areas may also be involved. The lesions typically range from 0.5 cm to 10 cm in diameter and are usually well-defined, non-inflammatory, and devoid of epidermis and, in a few cases, dermis or deeper tissues. The exact aetiology of ACC remains uncertain, though various causative factors have been proposed, including genetic mutations, intrauterine vascular compromise, maternal infections, teratogenic drug exposure during pregnancy, fetus papyraceus, and traumatic events during delivery. This case report presents an unusual case of isolated ACC, corresponding to Group VII of Frieden’s classification, involving the unilateral lower limb of a one-day-old full-term neonate, without any associated anomalies or systemic involvement. The lesion was present at birth, sharply demarcated, and devoid of signs of infection or ulceration. Conservative local wound care and gentle debridement were performed. Remarkably, the affected area showed spontaneous epithelialisation over the following weeks, healing completely without residual scarring or the need for surgical grafting. This case underscores the importance of recognising rare presentations of ACC beyond the scalp, as well as the potential for favourable outcomes with minimal intervention in selected cases. Early diagnosis, exclusion of underlying syndromic associations, and careful monitoring are essential for optimal management and prognosis. Keywords : Congenital condition, Debridement, Genetic mutation, Non-inflammatory skin lesion DOI and Others : DOI: 10.7860/IJNMR/2026/80185.2467 Date of Submission: Apr 25, 2025 Date of Peer Review: Aug 06, 2025 Date of Acceptance: Nov 10, 2025 Date of Publishing: Mar 31, 2026 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. Yes PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: May 03, 2025 • Manual Googling: Oct 17, 2025 • iThenticate Software: Nov 08, 2025 (5%) ETYMOLOGY: Author Origin EMENDATIONS: 6

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