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Year :2021
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Month :
October
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Volume :
9
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Issue :
4
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Page :
PC04 - PC06
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Neonatal Multisystem Inflammatory Syndrome Associated with Passive Transfer of Antibodies
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Correspondence Address :
Lokeswari Balleda, Sravani Kolla, Sai Kiran Pasupula, Chandrasekhara Reddy Thimmapuram,
Dr. Lokeswari Balleda,
Senior Consultant, Sri Ramachandra Children’s and Dental Hospital, Guntur, Andhra Pradesh, India.
E-mail: lballeda@gmail.com
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Multisystem Inflammatory Syndrome in Children (MIS-C) is a postinfection immune-mediated condition, seen four to six weeks after Coronavirus Disease-2019 (COVID-19). Multisystem Inflammatory Syndrome in Neonates (MIS-N) is a similar hyperinflammatory syndrome seen among neonates. The exact mechanism of MIS-N is not clear. The transplacental transfer of antibodies from Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infected mothers may lead to hyperinflammatory response among the neonates. In the current case report, the first 36-week-gestational-age male baby presented with respiratory symptoms and increased coronary Z scores which responded well to Intravenous Immunoglobulins (i.v. IG), steroids, and aspirin. The second 36-week-gestational-age male baby presented with unusual recurrent apnoeic attacks for that gestation (36 weeks) which responded dramatically to i.v IG and steroids. Immunoglobulins play a key role in the management of MIS-N.
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